Mumbai, India –29 May 2025, Advent, a pioneer in high-purity laboratory reagents, has launched two specialized solvent grades—LN (Low Non-volatile) and LCN (Low Non-volatile Chromatography)—to address a long-standing challenge in research and pharmaceutical labs: hidden impurities in solvents that compromise analytical precision.
The idea behind these solvents originated from a common frustration shared by scientists. In a recent feature titled “Behind the Breakthroughs,” Dr. Mohanty recounted an early-career incident where a clean NMR spectrum was suddenly disrupted by a mysterious peak. After exhaustive checks on reactants, equipment, and protocols, the team traced the issue back to the most unsuspecting culprit—a solvent. This experience inspired Advent to ask a critical question: Can we engineer solvents so pure that they silently support research without leaving a trace?
LN and LCN solvents were created to meet that very need. LN solvents are ideal for reaction and compound isolation processes, where solvent residues can skew results and delay drug development. Each batch undergoes a proprietary Proton NMR-based residual analysis. The solvent is completely evaporated, and any residue is re-dissolved and scanned via ¹H NMR. If no peaks appear in aromatic or aliphatic regions, the absence of organic impurities is confirmed. This process ensures that LN solvents evaporate cleanly and leave behind no detectable interference.
LCN solvents take this a step further by combining the purity of LN solvents with the stringent quality checks required for analytical and preparative HPLC. In addition to residual NMR analysis, LCN solvents are evaluated for UV absorbance, transmittance, moisture content, and residue on evaporation. These properties make them highly suitable for techniques where signal clarity and reproducibility are critical.
Both LN and LCN solvents are now widely adopted in R&D and CRO labs, especially in early-stage drug discovery where even minor impurities can have significant consequences. These solvents are designed to minimize the risk of ghost peaks, erroneous data, and compromised workflows. Though LCN solvents come at a slightly higher cost, they offer unmatched confidence and performance in demanding analytical environments.
Advent has also secured trademark registrations for LN and LCN, underscoring its commitment to setting a new industry standard in solvent purity. These solvents are available in 2.5 L, 4 L, 25 L, and 50 L stainless steel drums, catering to varying lab needs.
To see the full story and learn more about the role of solvent purity in pharmaceutical research, visit Advent’s website or watch Dr. Mohanty’s experience on YouTube.