The demand for complex, custom peptide sequences in pharmaceutical research continues to grow rapidly. At the heart of this growth lies the critical importance of high-quality, well-protected peptide building blocks — and this is precisely where Fmoc-β-Ala-His(Mmt)-OH makes its mark.
Understanding Fmoc-β-Ala-His(Mmt)-OH
Fmoc-β-Ala-His(Mmt)-OH is a specialized protected dipeptide building block designed for advanced Fmoc-based Solid Phase Peptide Synthesis (SPPS). With a molecular formula of C₄₄H₄₀N₄O₆ and a molecular weight of 720.81 g/mol, it belongs to the category of Peptide Working Standards and Intermediates.
The molecule combines β-alanine with Mmt-protected histidine — offering a dual protection strategy critical for complex peptide chain assembly. The Fmoc group ensures compatibility with standard Fmoc-SPPS protocols, while Mmt protection of the histidine side chain enables selective, orthogonal deprotection without disrupting the rest of the peptide sequence — making it particularly valuable for challenging synthesis workflows.
ADVENT's Achievement
ADVENT's R&D team successfully developed Fmoc-β-Ala-His(Mmt)-OH and scaled it from mg to gram scale — demonstrating the capability to translate a specialized building block from laboratory development to higher-scale preparation. The material has been comprehensively characterised using:
HPLC — purity determination and chromatographic profiling
Mass Spectrometry (MS) — molecular weight and structural confirmation
NMR Spectroscopy — definitive structural elucidation
FT-IR Spectroscopy — functional group identification
Achieved at greater than 95% HPLC purity with full analytical documentation ensuring structural integrity and batch-to-batch consistency.
Applications
Advanced peptide synthesis using Fmoc-based SPPS
Synthesis of complex and customized peptide sequences
Pharmaceutical R&D and custom peptide development
Peptide impurity and reference standard research
Analytical method development and characterization
Ready to Support Your Programme
Fmoc-β-Ala-His(Mmt)-OH is available for prompt dispatch. For technical specifications, analytical data, or custom peptide building block discussions, the ADVENT team is ready to engage. In peptide synthesis, the quality of your building block defines the integrity of your final sequence.
